The recommended dose of CYKLOKAPRON is 10 mg/kg actual body weight intravenously administered as a single dose, immediately before tooth extractions Infuse no more than 1 mL/minute to avoid hypotension [see Warnings and Precautions (5.1)]. Following tooth extraction, CYKLOKAPRON may be administered for 2 to 8 days at a dose of 10 mg/kg actual body weight 3 to 4 times daily, intravenously.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
For intravenous infusion, CYKLOKAPRON Injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions, and Dextran solutions. Heparin may be added to CYKLOKAPRON Injection. CYKLOKAPRON Injection should NOT be mixed with blood. The drug is a synthetic amino acid and should NOT be mixed with solutions containing penicillin.
Discard any unused portion.
The diluted mixture may be stored for up to 4 hours at room temperature prior to patient administration.
For patients with moderate to severe impaired renal function, the following dosages are recommended:
| Serum Creatinine (mg/dL) | CYKLOKAPRON Intravenous Dosage |
|---|---|
| * Dose reduction is recommended for all doses, both before and after tooth extraction. | |
1.36 to 2.83 | 10 mg/kg twice daily |
2.83 to 5.66 (250 to 500 micromol/L) | 10 mg/kg daily |
>5.66 (>500 micromol/L) | 10 mg/kg every 48 hours |
The recommended dose of CYKLOKAPRON is 10 mg/kg actual body weight intravenously administered as a single dose, immediately before tooth extractions Infuse no more than 1 mL/minute to avoid hypotension [see Warnings and Precautions (5.1)]. Following tooth extraction, CYKLOKAPRON may be administered for 2 to 8 days at a dose of 10 mg/kg actual body weight 3 to 4 times daily, intravenously.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
For intravenous infusion, CYKLOKAPRON Injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions, and Dextran solutions. Heparin may be added to CYKLOKAPRON Injection. CYKLOKAPRON Injection should NOT be mixed with blood. The drug is a synthetic amino acid and should NOT be mixed with solutions containing penicillin.
Discard any unused portion.
The diluted mixture may be stored for up to 4 hours at room temperature prior to patient administration.
For patients with moderate to severe impaired renal function, the following dosages are recommended:
| Serum Creatinine (mg/dL) | CYKLOKAPRON Intravenous Dosage |
|---|---|
| * Dose reduction is recommended for all doses, both before and after tooth extraction. | |
1.36 to 2.83 | 10 mg/kg twice daily |
2.83 to 5.66 (250 to 500 micromol/L) | 10 mg/kg daily |
>5.66 (>500 micromol/L) | 10 mg/kg every 48 hours |
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