metoprolol tartrate injection, USP - VIAL Highlights

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use METOPROLOL TARTRATE INJECTION safely and effectively. See full prescribing information for METOPROLOL TARTRATE INJECTION

METOPROLOL TARTRATE Injection, for intravenous use
Initial U.S. Approval: 1978

RECENT MAJOR CHANGES

Warnings and Precautions, Hypoglycemia (5.5)

5/2024

INDICATIONS AND USAGE

Metoprolol tartrate is a beta-adrenergic receptor inhibitor indicated for the treatment of definite or suspected acute myocardial infarction in hemodynamically stable patients to reduce cardiovascular mortality when used in conjunction with oral metoprolol maintenance therapy. (1)

DOSAGE AND ADMINISTRATION

•
Initiate therapy in a coronary care or similar unit immediately after the patients hemodynamic condition has stabilized. (2)
•
Begin treatment with an intravenous administration of three bolus injections of 5 mg each, at approximately 2-minute intervals. Monitor blood pressure, heart rate and electrocardiogram. (2)
•
Following administration of Metoprolol tartrate Injection, transition the patient to an oral formulation of metoprolol. (2)

DOSAGE FORMS AND STRENGTHS

Injection: 5 mg metoprolol tartrate supplied in Single-dose glass Fliptop Vial. (3)

CONTRAINDICATIONS

•
Known hypersensitivity to product components. (4)
•
Severe bradycardia, greater than first degree heart block, or sick sinus syndrome without a pacemaker. (4)
•
Cardiogenic shock or decompensated heart failure. (4)

WARNINGS AND PRECAUTIONS

•
Worsening cardiac failure may occur. (5.2)
•
Bronchospastic Disease: Avoid beta-blockers. (5.3)
•
Pheochromocytoma: First initiate therapy with an alpha blocker. (5.4)
•
May aggravate symptoms of arterial insufficiency. (5.6)

ADVERSE REACTIONS

•
Most common adverse reactions: tiredness, dizziness, shortness of breath, bradycardia, hypotension, pruritus. (6.1)

To report SUSPECTED ADVERSE REACTIONS, contact Hospira, Inc. at 1-800-441-4100 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

DRUG INTERACTIONS

•
Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. (7.1)
•
Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (7.2)
•
CYP2D6 Inhibitors are likely to increase metoprolol concentration. (7.3)
•
Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. (7.4)
•
Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine. (7.4)

USE IN SPECIFIC POPULATIONS

•
Hepatic Impairment: Consider initiating metoprolol tartrate therapy at low doses while monitoring closely for adverse events. (8.6)

See 17 for PATIENT COUNSELING INFORMATION.

Revised: 5/2024

Find metoprolol tartrate injection, USP - VIAL medical information:

Find metoprolol tartrate injection, USP - VIAL medical information:

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

metoprolol tartrate injection, USP - VIAL Quick Finder

Prescribing Information
Download Prescribing Information

Health Professional Information

Highlights

HIGHLIGHTS OF PRESCRIBING INFORMATION

These highlights do not include all the information needed to use METOPROLOL TARTRATE INJECTION safely and effectively. See full prescribing information for METOPROLOL TARTRATE INJECTION

METOPROLOL TARTRATE Injection, for intravenous use
Initial U.S. Approval: 1978

RECENT MAJOR CHANGES

Warnings and Precautions, Hypoglycemia (5.5)

5/2024

INDICATIONS AND USAGE

Metoprolol tartrate is a beta-adrenergic receptor inhibitor indicated for the treatment of definite or suspected acute myocardial infarction in hemodynamically stable patients to reduce cardiovascular mortality when used in conjunction with oral metoprolol maintenance therapy. (1)

DOSAGE AND ADMINISTRATION

•
Initiate therapy in a coronary care or similar unit immediately after the patients hemodynamic condition has stabilized. (2)
•
Begin treatment with an intravenous administration of three bolus injections of 5 mg each, at approximately 2-minute intervals. Monitor blood pressure, heart rate and electrocardiogram. (2)
•
Following administration of Metoprolol tartrate Injection, transition the patient to an oral formulation of metoprolol. (2)

DOSAGE FORMS AND STRENGTHS

Injection: 5 mg metoprolol tartrate supplied in Single-dose glass Fliptop Vial. (3)

CONTRAINDICATIONS

•
Known hypersensitivity to product components. (4)
•
Severe bradycardia, greater than first degree heart block, or sick sinus syndrome without a pacemaker. (4)
•
Cardiogenic shock or decompensated heart failure. (4)

WARNINGS AND PRECAUTIONS

•
Worsening cardiac failure may occur. (5.2)
•
Bronchospastic Disease: Avoid beta-blockers. (5.3)
•
Pheochromocytoma: First initiate therapy with an alpha blocker. (5.4)
•
May aggravate symptoms of arterial insufficiency. (5.6)

ADVERSE REACTIONS

•
Most common adverse reactions: tiredness, dizziness, shortness of breath, bradycardia, hypotension, pruritus. (6.1)

To report SUSPECTED ADVERSE REACTIONS, contact Hospira, Inc. at 1-800-441-4100 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

DRUG INTERACTIONS

•
Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. (7.1)
•
Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (7.2)
•
CYP2D6 Inhibitors are likely to increase metoprolol concentration. (7.3)
•
Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. (7.4)
•
Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine. (7.4)

USE IN SPECIFIC POPULATIONS

•
Hepatic Impairment: Consider initiating metoprolol tartrate therapy at low doses while monitoring closely for adverse events. (8.6)

See 17 for PATIENT COUNSELING INFORMATION.

Revised: 5/2024
Medication Guide

Health Professional Information

{{section_name_patient}}

{{section_body_html_patient}}

Resources

Didn’t find what you were looking for? Contact us.

MI Digital Assistant

Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine.

Call 800-438-1985*

*Speak with a Pfizer Medical Information Professional regarding your medical inquiry. Available 9AM-5PM ET Monday to Friday; excluding holidays.

Medical Inquiry

Submit a medical question for Pfizer prescription products.

Report Adverse Event

Pfizer Safety

To report an adverse event related to the Pfizer-BioNTech COVID-19 Vaccine, and you are not part of a clinical trial* for this product, click the link below to submit your information:

Pfizer Safety Reporting Site

*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.

If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.