morphine sulfate injection, USP NEXJECT, CARPUJECT Patient Counseling Information

17 PATIENT COUNSELING INFORMATION

Addiction, Abuse, and Misuse

Inform patients that the use of Morphine Sulfate Injection, even when taken as recommended, can result ‎in addiction, abuse, and misuse, which can lead to overdose and death [see Warnings and Precautions ‎‎(5.1)]. Instruct patients not to share Morphine Sulfate Injection with others and to take steps to protect ‎Morphine Sulfate Injection from theft or misuse.‎

Life-Threatening Respiratory Depression

Inform patients of the risk of life-threatening respiratory depression, including information that the risk is ‎greatest when starting Morphine Sulfate Injection or when the dosage is increased, and that it can occur ‎even at recommended dosages [see Warnings and Precautions (5.2)]. ‎

Hyperalgesia and Allodynia

Advise patients to inform their healthcare provider if they ‎experience symptoms of hyperalgesia, including worsening pain, increased ‎sensitivity to pain, or new pain [see Warnings and Precautions (5.6); ‎Adverse Reactions (6)].‎

Serotonin Syndrome

Opioids can cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. Instruct patients to inform their physicians if they are taking, or plan to take serotonergic medications [see Drug Interactions (7)].

Constipation

Advise patients of the potential for severe constipation, including management instructions and when to seek medical attention [see Adverse Reactions (6)].

For Medical Information about [Morphine Sulfate Injection], please visit www.pfizermedinfo.com or call 1-800-438-1985.

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Patient Counseling Information

17 PATIENT COUNSELING INFORMATION

Addiction, Abuse, and Misuse

Inform patients that the use of Morphine Sulfate Injection, even when taken as recommended, can result ‎in addiction, abuse, and misuse, which can lead to overdose and death [see Warnings and Precautions ‎‎(5.1)]. Instruct patients not to share Morphine Sulfate Injection with others and to take steps to protect ‎Morphine Sulfate Injection from theft or misuse.‎

Life-Threatening Respiratory Depression

Inform patients of the risk of life-threatening respiratory depression, including information that the risk is ‎greatest when starting Morphine Sulfate Injection or when the dosage is increased, and that it can occur ‎even at recommended dosages [see Warnings and Precautions (5.2)]. ‎

Hyperalgesia and Allodynia

Advise patients to inform their healthcare provider if they ‎experience symptoms of hyperalgesia, including worsening pain, increased ‎sensitivity to pain, or new pain [see Warnings and Precautions (5.6); ‎Adverse Reactions (6)].‎

Serotonin Syndrome

Opioids can cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. Instruct patients to inform their physicians if they are taking, or plan to take serotonergic medications [see Drug Interactions (7)].

Constipation

Advise patients of the potential for severe constipation, including management instructions and when to seek medical attention [see Adverse Reactions (6)].

For Medical Information about [Morphine Sulfate Injection], please visit www.pfizermedinfo.com or call 1-800-438-1985.

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