BRAFTOVI® What is the most important information I should know about BRAFTOVI?

(encorafenib)

What is the most important information I should know about BRAFTOVI?

BRAFTOVI may cause serious side effects, including:

•: Risk of new skin cancers. BRAFTOVI when used alone, or with binimetinib or cetuximab, may cause skin cancers called cutaneous squamous cell carcinoma or basal cell carcinoma.
Talk to your healthcare provider about your risk for these cancers.
Check your skin and tell your healthcare provider right away about any skin changes, including a:

o: new wart
o: skin sore or reddish bump that bleeds or does not heal
o: change in size or color of a mole

: Your healthcare provider should check your skin before treatment with BRAFTOVI, every 2 months during treatment, and for up to 6 months after you stop treatment with BRAFTOVI to look for any new skin cancers.
: Your healthcare provider should also check for cancers that may not occur on the skin. Tell your healthcare provider about any new symptoms that develop during treatment with BRAFTOVI.
: See "What are the possible side effects of BRAFTOVI?" for more information about side effects.

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What is the most important information I should know about BRAFTOVI?

BRAFTOVI may cause serious side effects, including:

•: Risk of new skin cancers. BRAFTOVI when used alone, or with binimetinib or cetuximab, may cause skin cancers called cutaneous squamous cell carcinoma or basal cell carcinoma.
Talk to your healthcare provider about your risk for these cancers.
Check your skin and tell your healthcare provider right away about any skin changes, including a:

o: new wart
o: skin sore or reddish bump that bleeds or does not heal
o: change in size or color of a mole

: Your healthcare provider should check your skin before treatment with BRAFTOVI, every 2 months during treatment, and for up to 6 months after you stop treatment with BRAFTOVI to look for any new skin cancers.
: Your healthcare provider should also check for cancers that may not occur on the skin. Tell your healthcare provider about any new symptoms that develop during treatment with BRAFTOVI.
: See "What are the possible side effects of BRAFTOVI?" for more information about side effects.

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Health Professional Information

What is the most important information I should know about BRAFTOVI?

BRAFTOVI may cause serious side effects, including:

•: Risk of new skin cancers. BRAFTOVI when used alone, or with binimetinib or cetuximab, may cause skin cancers called cutaneous squamous cell carcinoma or basal cell carcinoma.
Talk to your healthcare provider about your risk for these cancers.
Check your skin and tell your healthcare provider right away about any skin changes, including a:

o: new wart
o: skin sore or reddish bump that bleeds or does not heal
o: change in size or color of a mole

: Your healthcare provider should check your skin before treatment with BRAFTOVI, every 2 months during treatment, and for up to 6 months after you stop treatment with BRAFTOVI to look for any new skin cancers.
: Your healthcare provider should also check for cancers that may not occur on the skin. Tell your healthcare provider about any new symptoms that develop during treatment with BRAFTOVI.
: See "What are the possible side effects of BRAFTOVI?" for more information about side effects.

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