PREMPRO® AND PREMPHASE® What are the possible side effects of PREMPRO or PREMPHASE?

(conjugated estrogens and medroxyprogesterone acetate)

What are the possible side effects of PREMPRO or PREMPHASE?

Side effects are grouped by how serious they are and how often they happen when you are treated.

Serious, but less common side effects include:

•
Heart attack
•
Stroke
•
Blood clots
•
Dementia
•
Breast cancer
•
Cancer of the lining of the uterus (womb)
•
Cancer of the ovary
•
High blood pressure
•
High blood sugar
•
Gallbladder disease
•
Liver problems
•
Enlargement of benign tumors of the uterus ("fibroids")
•
Mental depression
•
Severe allergic reaction

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

•
New breast lumps
•
Unusual vaginal bleeding
•
Changes in vision or speech
•
Sudden new severe headaches
•
Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue
•
Swollen lips, tongue and face

Less serious, but common side effects include:

•
Headache
•
Breast pain
•
Irregular vaginal bleeding or spotting
•
Stomach or abdominal cramps, bloating
•
Nausea and vomiting
•
Hair loss
•
Fluid retention
•
Vaginal yeast infection

These are not all the possible side effects of PREMPRO or PREMPHASE. For more information, ask your healthcare provider or pharmacist for advice about side effects. You may report side effects to Pfizer Inc. at 1-800-438-1985 or to FDA at 1-800-FDA-1088.

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Health Professional Information

What are the possible side effects of PREMPRO or PREMPHASE?

What are the possible side effects of PREMPRO or PREMPHASE?

Side effects are grouped by how serious they are and how often they happen when you are treated.

Serious, but less common side effects include:

•
Heart attack
•
Stroke
•
Blood clots
•
Dementia
•
Breast cancer
•
Cancer of the lining of the uterus (womb)
•
Cancer of the ovary
•
High blood pressure
•
High blood sugar
•
Gallbladder disease
•
Liver problems
•
Enlargement of benign tumors of the uterus ("fibroids")
•
Mental depression
•
Severe allergic reaction

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

•
New breast lumps
•
Unusual vaginal bleeding
•
Changes in vision or speech
•
Sudden new severe headaches
•
Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue
•
Swollen lips, tongue and face

Less serious, but common side effects include:

•
Headache
•
Breast pain
•
Irregular vaginal bleeding or spotting
•
Stomach or abdominal cramps, bloating
•
Nausea and vomiting
•
Hair loss
•
Fluid retention
•
Vaginal yeast infection

These are not all the possible side effects of PREMPRO or PREMPHASE. For more information, ask your healthcare provider or pharmacist for advice about side effects. You may report side effects to Pfizer Inc. at 1-800-438-1985 or to FDA at 1-800-FDA-1088.

Prescribing Information
Download Prescribing Information

Health Professional Information

What are the possible side effects of PREMPRO or PREMPHASE?

What are the possible side effects of PREMPRO or PREMPHASE?

Side effects are grouped by how serious they are and how often they happen when you are treated.

Serious, but less common side effects include:

•
Heart attack
•
Stroke
•
Blood clots
•
Dementia
•
Breast cancer
•
Cancer of the lining of the uterus (womb)
•
Cancer of the ovary
•
High blood pressure
•
High blood sugar
•
Gallbladder disease
•
Liver problems
•
Enlargement of benign tumors of the uterus ("fibroids")
•
Mental depression
•
Severe allergic reaction

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

•
New breast lumps
•
Unusual vaginal bleeding
•
Changes in vision or speech
•
Sudden new severe headaches
•
Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue
•
Swollen lips, tongue and face

Less serious, but common side effects include:

•
Headache
•
Breast pain
•
Irregular vaginal bleeding or spotting
•
Stomach or abdominal cramps, bloating
•
Nausea and vomiting
•
Hair loss
•
Fluid retention
•
Vaginal yeast infection

These are not all the possible side effects of PREMPRO or PREMPHASE. For more information, ask your healthcare provider or pharmacist for advice about side effects. You may report side effects to Pfizer Inc. at 1-800-438-1985 or to FDA at 1-800-FDA-1088.

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Report Adverse Event

Pfizer Safety

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If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.