PREMARIN® VAGINAL CREAM Contraindications

(conjugated estrogens)

4 CONTRAINDICATIONS

PREMARIN Vaginal Cream therapy should not be used in women with any of the following conditions:

•
Undiagnosed abnormal genital bleeding
•
Known, suspected, or history of breast cancer
•
Known or suspected estrogen-dependent neoplasia
•
Active DVT, PE, or a history of these conditions
•
Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
•
Known anaphylactic reaction or angioedema to PREMARIN Vaginal Cream
•
Known liver dysfunction or disease
•
Known protein C, protein S or antithrombin deficiency or other known thrombophilic disorders
•
Known or suspected pregnancy

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Contraindications

4 CONTRAINDICATIONS

PREMARIN Vaginal Cream therapy should not be used in women with any of the following conditions:

•
Undiagnosed abnormal genital bleeding
•
Known, suspected, or history of breast cancer
•
Known or suspected estrogen-dependent neoplasia
•
Active DVT, PE, or a history of these conditions
•
Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
•
Known anaphylactic reaction or angioedema to PREMARIN Vaginal Cream
•
Known liver dysfunction or disease
•
Known protein C, protein S or antithrombin deficiency or other known thrombophilic disorders
•
Known or suspected pregnancy
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