PREMPRO® AND PREMPHASE® Contraindications

(conjugated estrogens and medroxyprogesterone acetate)

4 CONTRAINDICATIONS

PREMPRO or PREMPHASE therapy should not be used in women with any of the following conditions:

•
Undiagnosed abnormal genital bleeding
•
Known, suspected, or history of breast cancer
•
Known or suspected estrogen-dependent neoplasia
•
Active DVT, PE, or a history of these conditions
•
Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
•
Known anaphylactic reaction or angioedema to PREMPRO/PREMPHASE
•
Known liver dysfunction or disease
•
Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
•
Known or suspected pregnancy

Find PREMPRO® AND PREMPHASE® medical information:

Find PREMPRO® AND PREMPHASE® medical information:

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

PREMPRO® AND PREMPHASE® Quick Finder

Prescribing Information
Download Prescribing Information

Health Professional Information

Contraindications

4 CONTRAINDICATIONS

PREMPRO or PREMPHASE therapy should not be used in women with any of the following conditions:

•
Undiagnosed abnormal genital bleeding
•
Known, suspected, or history of breast cancer
•
Known or suspected estrogen-dependent neoplasia
•
Active DVT, PE, or a history of these conditions
•
Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
•
Known anaphylactic reaction or angioedema to PREMPRO/PREMPHASE
•
Known liver dysfunction or disease
•
Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
•
Known or suspected pregnancy
Medication Guide

Health Professional Information

{{section_name_patient}}

{{section_body_html_patient}}

Resources

Didn’t find what you were looking for? Contact us.

MI Digital Assistant

Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine.

Call 800-438-1985*

*Speak with a Pfizer Medical Information Professional regarding your medical inquiry. Available 9AM-5PM ET Monday to Friday; excluding holidays.

Medical Inquiry

Submit a medical question for Pfizer prescription products.

Report Adverse Event

Pfizer Safety

To report an adverse event related to the Pfizer-BioNTech COVID-19 Vaccine, and you are not part of a clinical trial* for this product, click the link below to submit your information:

Pfizer Safety Reporting Site

*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.

If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.

FDA Medwatch

You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.