Too rapid administration and/or excessive amounts of tromethamine may cause alkalosis, hypoglycemia, overhydration or solute overload. In the event of overdosage, discontinue the infusion, evaluate the patient and institute appropriate countermeasures (see WARNINGS, PRECAUTIONS and ADVERSE REACTIONS).
The LD50 values for the acute intravenous toxicity of THAM are influenced by the rate of infusion of the dose administered.
Intravenous LD50 Mice = 3,500 mg/kg
Intravenous LD50 Rats = 2,300 mg/kg
Too rapid administration and/or excessive amounts of tromethamine may cause alkalosis, hypoglycemia, overhydration or solute overload. In the event of overdosage, discontinue the infusion, evaluate the patient and institute appropriate countermeasures (see WARNINGS, PRECAUTIONS and ADVERSE REACTIONS).
The LD50 values for the acute intravenous toxicity of THAM are influenced by the rate of infusion of the dose administered.
Intravenous LD50 Mice = 3,500 mg/kg
Intravenous LD50 Rats = 2,300 mg/kg
Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine.
*Speak with a Pfizer Medical Information Professional regarding your medical inquiry. Available 9AM-5PM ET Monday to Friday; excluding holidays.
Submit a medical question for Pfizer prescription products.
Pfizer Safety
To report an adverse event related to the Pfizer-BioNTech COVID-19 Vaccine, and you are not part of a clinical trial* for this product, click the link below to submit your information:
Pfizer Safety Reporting Site*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.
If you cannot use the above website, or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985.
FDA Medwatch
You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at www.fda.gov/medwatch or call (800) 822-7967.